Nuclear Magnetic Resonance (NMR)

Nuclear Magnetic Resonance (NMR) spectroscopy is an invaluable tool for the characterization of chemical entities. Its power is unparalleled in the identification of organic and biochemical compounds, and can be harnessed to characterize many inorganic and organometallic substances, as well. The quantitative nature of NMR is routinely utilized to determine co-polymer ratios and quantify impurities.

Used in concert with complementary analytical techniques offered at Exova, such as Fourier Transform Infrared Spectroscopy (FT-IR), elemental analysis, and mass spectrometry, NMR is particularly useful to projects aimed at identification of chemical and pharmaceutical unknowns.

Its capabilities extend to structure elucidation of degradants and reaction side products, determination of relative stereochemistry, and conformational analysis which is useful with peptides and small proteins.

NMR spectroscopy for a range of industrial sectors

Our NMR services are targeted primarily to customers in the biotechnology, pharmaceutical, specialty chemical, medical device, nutraceutical, personal care, oil, and petrochemical industries.

Our NMR spectrometer is equipped with probe heads capable of analysing samples in solution state by the majority of modern one- and two-dimensional (1D and 2D) NMR experiments.

cGMP-compliant NMR system

Exova has one of the few cGMP-compliant NMR systems existing in commercial laboratories.
The system is operationally qualified annually for instrument parameters such as sensitivity, resolution, line shape, and pulse width for various nuclei (1H, 13C, 19F, 29Si and 31P).

The instrument software has been rigorously challenged to ensure data integrity. Operators are qualified through documented training. While the NMR system is used for several GMP compendia tests, Exova also provides research, method development and validation in accordance with ICH guidelines.

Heparin testing

NMR is a general technique that can be used to detect any 1H-containing impurity and in the case of OSCS, it identifies the N-acetyl methyl peak of the adulterant which has a different chemical shift than the same functional group in heparin.

Our Bruker Avance III 500 MHz NMR Spectrometer provides sufficient resolution to distinguish between the N-acetyl methyl signals of heparin, dermatan sulfate, and OSCS, and sufficient sensitivity to observe impurities down to 0.1% w/w. The instrument is cGMP and has been audited by the FDA specifically for contract test of Heparin.

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Pharmaceutical testing facilities

2395 Speakman Dr.,
Mississauga, ON L5K 1B3

Contact: Larissa Hillar - Operations Manager
Tel: +1 905 822 4111

Fax: +1 905 823 1446


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9240 Santa Fe Springs Road,
Santa Fe Springs, CA 90670

Contact: Eric Lindsay - General Manager
Tel: +1 562 948 2225

Fax: +1 562 948 5850


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Plot 598-221, Dubai Investments Park 1, The Green Community, P.O. Box: 34924,

Contact: Jason Dodds - Managing Director
Tel: +971 4 885 1001

Fax: +971 4 885 4004


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