| Analytical chemistry & method development- Pharmaceutical Exova Health Sciences has extensive experience in pharmaceutical chemistry and analytical methods. We have worked with a wide range of companies on almost all formulation types and on projects which have involved analysing a diverse variety of compound types at all stages of development. Our wide ranging experience has lead to the development of many new and innovative analytical solutions alongside implementing or modifying well-established methods in our accredited laboratories.
Our analytical capability is regularly extended and developed to meet clients' requirements and we work with our clients to increase their available resource, decrease the potential for delays in the development process and provide an independent validation.
Our analytical activities include:- method development and validation to support the synthesis of drug substances and intermediates, formulation development and formulated product manufacture as well as cleaning validation activities
- analytical technology transfer of clients' methods to support development and stability studies
- compatibility and pre-formulation support
- stability testing of drug substances and formulated products
- long-term storage of stability samples in accordance with ICH guidelines
- temperature, humidity and light requirements in validated, monitored cabinets
- reference material characterisation, certification, control and distribution
- QC release testing
- analytical consultancy services
Techniques include:- HPLC with variable wavelength, diode array, refractive index or pulsed amperometric detection
- HPLC-MS (APCI or ESI)
- GC (headspace or on-column) with flame ionisation, electron capture or thermal conductivity detection
- GC-MS (EI quad)
- Ion Chromatography
- Thin layer chromatography
- FTIR with disc, DRIFT or ATR
- UV-visible spectrophotometry, with dual beam or diode array detection
- Atomic absorption (flame and furnace)
- Total organic carbon determination
- Auto titration
- Moisture determination - coulometric KF titration, direct sample introduction and vapouriser
- Dissolution testing
- Particle sizing and sub-visible particle determination
- Wide variety of physical testing techniques
For further information regarding our specialist services, please email healthsciences@Exova.com or call us on +44 (0)121 206 4120.
|
|
|
Return